Prostate Cancer Risk and ESR1 TA, ESR2 CA Repeat Polymorphisms
نویسندگان
چکیده
منابع مشابه
Prostate cancer risk and ESR1 TA, ESR2 CA repeat polymorphisms.
BACKGROUND Experimental evidence has suggested that estrogen receptor alpha (coded by the gene ESR1) might increase prostate cancer risk, whereas estrogen receptor beta (coded by the gene ESR2) might reduce prostate cancer risk. METHODS We investigated the relationship with prostate cancer risk of both a TA repeat polymorphism in the ESR1 5' region, ESR1 (TA)(n), and with a CA repeat polymorp...
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Background:Prostate cancer is increasing among Iranian men and gene polymorphisms may play a role in the development of prostate cancer. Insulin-like growth factor 1 (IGF1) gene polymorphisms have been deeply explored in different malignancies. In this study, we aimed to explore the association of IGF1 CA repeat length polymorphism with the risk of prostate cancer development i...
متن کاملGenetic polymorphisms of ESR1 and ESR2 that may influence estrogen activity and the risk of hypospadias.
BACKGROUND The etiology of hypospadias is regarded as a complex disorder with both genetic and environmental contributions. Although alterations in androgen activity have been associated with hypospadias, few associations with estrogen activity have been documented. Here, we assessed genetic polymorphisms in estrogen receptor genes and their association with hypospadias. METHODS Using a case-...
متن کاملESR1 Gene Polymorphisms and Prostate Cancer Risk: A HuGE Review and Meta-Analysis
BACKGROUND Many published data on the association between single nucleotide polymorphisms (SNPs) in the ESR1 gene and prostate cancer susceptibility are inconclusive. The aim of this Human Genome Epidemiology (HuGE) review and meta-analysis is to derive a more precise estimation of this relationship. METHODS A literature search of PubMed, Embase, Web of Science and Chinese Biomedical (CBM) da...
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Estrogen may be involved in the development of prostate cancer. The association between genetic polymorphisms of estrogen receptors alpha (ESR1) and beta (ESR2) and prostate cancer risk was examined in a nested case-control study in Washington County, Maryland. Incident prostate cancer cases (n = 269) were matched to one or two controls (n = 440) by age, sex, race, and date of blood donation. A...
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ژورنال
عنوان ژورنال: Cancer Epidemiology Biomarkers & Prevention
سال: 2007
ISSN: 1055-9965,1538-7755
DOI: 10.1158/1055-9965.epi-07-0481